Whole genome sequencing informs SNP-based breeding strategies to safeguard genetic diversity in captive African lions

Whole genome sequencing informs SNP-based breeding strategies to safeguard genetic diversity in captive African lions

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IntroductionAfrican lions (Panthera leo) face severe population declines, making captive breeding programs essential for conservation.However, genetic data roneverhart.com scarcity in such programs elevates inbreeding risks and threatens genetic diversity.MethodsUsing next-generation sequencing (NGS), we analyzed genome-wide genetic markers from 10 captive African lions at Xinjiang Tianshan Wildlife Park.

We identified high-confidence SNPs, evaluated population structure, and calculated kinship/inbreeding coefficients alongside identity by descent (IBD) and identity by state (IBS) analyses.ResultsWe identified 5,051,795 high-confidence SNPs.The population contained distinct genetic subgroups.

Six lion pairs exhibited elevated kinship coefficients, with one individual showing inbreeding signs.We developed a science-driven breeding program based on population genetic structure, identity by descent (IBD) analysis, and Identity by State (IBS) analysis.This program prioritizes pairings with low kinship while maintaining a balanced ancestral lineage.

DiscussionThis study underscores the importance of genomic tools in managing captive populations, offering actionable insights to mitigate inbreeding risks and improve long-term viability.This approach offers a model for optimizing breeding life extension blueberry extract strategies in other endangered species conservation efforts.